Enzo Gut Repair
ENZO Gut Repair Nutritional Support for Healthy Gut Function. A pre biotic formula, supporting healthy gut flora. It promotes growth of desirable gut bacteria and suppresses harmful bacteria. Further it promotes non-inflammed healthy gut cells, thereby helping to maintain healthy gut barrier function. Containing Enzogenol, NZ pine bark extract, POMx Pomegranate extract, Novasoy Soy Bean Extract and Teahealthy, Green tea extract. Ideal for those with problems related to gut dysbioses. 1 month supply. 60 Vegetable Capsules
Ultimate Nutrition For Healthy Gut Function. Boosting Your Nutrition for
- Healthy Beneficial Gut Flora
- Non-Inflammed Gut
- Healthy Gut-Barrier Function
- Healthy Gut-Immune System
- Healthy Gut-Brain Axis
Those who may benefit most from ENZO Gut Repair include those with:
- Digestive intolerances
- Gut inflammation and leakiness
- Metabolic imbalances
- Weight problems
- As well as brain, behaviour and psychological compaints often caused by gut dysbioses.
Adults: 2 capsules daily
Children: 1 capsule daily
Or as directed by your health care professional.
To achieve best results for your gut health, continue to take for at least 3 months.
Further Dosing Advice: BEFORE USE, please read this advice.
Dose for children age 3-6: Give one capsule per day in the morning before food. Higher dosing should not be necessary in very young children.
Dose for children age 7-12: For the first five days give 1 capsule per day.
If symptoms improve maintain this dose. If no improvements are noticed increase dose to 2 capsules per day taken as one dose in the morning before food.
Teenagers and Adults: Take 2 capsules in the morning before breakfast.
In cases of severe gut issues more doses may be necessary to affect healthy changes.
Additional doses can be taken, 1 or 2 capsules at a time, preferably before lunch and dinner.
How to take Enzo Gut Repair:
Preferably, capsules should be swallowed whole since the powder tastes astringent and possibly unpleasant to many people.
Preferably, take in the morning before food with a large glass of water (but can also be taken with food).
Doses can be split into two or more over the day. If a child does not swallow capsules you
can pull the capsule apart and mix the powder into mashed banana or other fruit. Sweetness masks the astringent taste best. Avoid milk products within 1 hr of taking the capsules since milk proteins may inactivate the product
This is what Enzo have to tell us about their ENZO Gut Repair Product
ENZO Gut Repair is specifically formulated to support gut health based on the latest scientific research.
ENZO Gut Repair is an entirely natural plant-based product that combines specific plant extracts from pine bark, green tea, soy beans and pomegranate which all promote a healthy gut. The formulation delivers effective dose levels of the extracts and their active compounds. Two capsules daily supply the appropriate and effective amount of the active plant compounds to balance your gut environment to a healthy state devoid of irritation, and able to effectively digest and absorb the nutrients in your food.
Importance of Gut Health
The health of our gut is critically important for our mental, and physical well-being. Nutritional science has shown how our food, and particularly the plant-nutrients in our food, contribute to the health of our gut walls, and maintain the beneficial populations of the many different types of gut bacteria that we live with in a symbiotic relationship.
The Specific Actives in ENZO Gut Repair
The specific combination of the plant-polyphenol compounds in ENZO Gut Repair make the formulation an exceptionally useful aid in achieving and maintaining a healthy gut. It is the combination of the different types of plant compounds that makes ENZO Gut Repair such an extraordinary formulation. Each polyphenol compound has a different molecular configuration that contributes a different range of activities working on different factors in the gut, calming irritation and improving health. Hence, the combination of plant compounds in ENZO Gut Repair delivers an effective broad spectrum of health benefits to the gut.
The ingredients of ENZO Gut Repair
Enzogenol® - New Zealand pine bark extract contains 80% proanthocyanidins that have strong anti-oxidant and natural anti-inflammatory properties that lead to reduced oxidative stress and irritation of the gut walls. Proanthocyanidins also act as pre-biotics which means that they promote a healthy gut flora, particularly by reducing the growth of unwanted, harmful types of bacteria in the gut.
TeaHeathyTM, Green tea extract from the fresh leaves of Camellia sinensis contains 50% EGCG, and a range of other healthy green tea polyphenols with exceptional anti-oxidant and natural anti-inflammatory properties. EGCG is a very potent health promoting polyphenol that has been studied extensively and is a key contributor to the health benefits of green tea.
POMx® , Pomegranate extract is a highly concentrated extract from Californian pomegranate fruit, and contains 40% punicalagins and elagic acid. These are special pomegranate polyphenols that are highly effective in supporting a healthy gut free of irritation.
Novasoy®, Soybean extract is a very high quality, Non-GMO, extract made from soy beans. It contains the soy isoflavones Genistein, Daidzein and Glycitein that support gut health. The higher consumption of these soy bean polyphenols is part of the reason that very few people in Asian countries suffer from bowel irritations.
Below is a selection of the research evidence that has shown how the particular plant polyphenols present in ENZO Gut Repair can affect gut inflammation, barrier function and microflora. (Full research papers available from ENZO Nutraceuticals Ltd)
Polyphenols are phytochemicals that are abundant in plant foods. Increased intake of polyphenols promotes the health of many organ systems in our body. The health benefits for the gut occur through the anti-inflammatory properties of the polyphenols which make these plant compounds a very important part of our diet. They can modulate the inflammatory response by getting into direct contact with the cells in our gut walls and changing their responses to several key factors controlling inflammation.
ENZO Gut Repair compounds can inhibit the response to several pro-inflammatory factors (in the NFκB and MAPK pathways) that are produced within our gut walls if we have an irritated bowel and consequently support lesser irritation and a re-balancing process in the gut. If the gut is not irritated ENZO Gut Repair will help to maintain gut heath and promote overall digestive health.
Research on Proanthocyanidins (PACs) and Piceatannol on Gut Health
PACs, which are the main polyphenol in Enzogenol, can increase the production of intestinal mucosal tight junction proteins in a rat model of postweaning diarrhea (Song). These are proteins responsible for the barrier function in the gut epithelium. In addition, this study also showed that PACs can also improve the anti-oxidant status of the gut epithelium (Song).
Piceatannol is a stilbene compound found in Enzogenol. It modifies multiple cellular targets by exerting immunosuppressive and antitumorigenic activities. In a mouse model of chemically induced colitis Piceatannol has been shown to slow down the development of colitis (Kim).
Pine bark extract has been shown to reduce mucosal damage in the gut in a rat model of chemically induced IBD (Mochizuki).
Research on Epigallocatechin-gallate (EGCG) and Gut Health
EGCG, the main polyphenol in TeaHealthy, can downregulate the inflammatory response in inflamed epithelial cells of the gut. EGCG has been shown to inhibit many of the inflammatory reactions that are involved in irritation and inflammation of the gut. EGCG significantly reduces the amount pro-inflammatory cytokines IL-6 and IL-8 produced by the gut, and by the immune cells. IL-6 stimulates the inflammatory and auto-immune reactions in the gut walls. IL-8 attracts neutrophils to the site of the gut irritation and promotes phagocytosis. EGCG downregulates the inflammatory response in inflamed intestinal epithelial cells by reducing pro-inflammatory cytokines IL-6 and IL-8 by 50-60% (Sergent).
The consumption of green tea has also been associated with lower rates of several cancers including bowel cancer, because EGCG can block each stage of cancer development by modulating signal transduction pathways involved in cell proliferation, transformation, inflammation, apoptosis, metastasis and invasion (Na).
Research on Catechin and Gut Health
Catechin, one of the main polyphenols in Enzogenol and in TeaHealthy, has been shown to reduce damage to the gut walls caused by inflammation. In a rat model of chemically induced ulcerative colitis catechin feeding led to a significant decrease in colon damage (Sato).
Research on Elagic Acid and Gut Health
Pomegranate (Punica granatum L.) has traditionally been used for the treatment of various inflammatory diseases, including ulcerative colitis. Because its extract, POMx, is rich in ellagitannins, which release ellagic acid when hydrolyzed, consumption of POMx has several potential health effects, including prevention of inflammatory diseases. Research in a chemically induced ulcerative colitis mouse model has shown how elagic acid can reduce inflammation and inhibit disease progression. In acute UC, ellagic acid ameliorates disease severity through the profile of inflammatory mediators (IL-6, TNF-α, and IFN-γ). In the chronic UC, ellagic acid inhibits the progression of the disease, reducing intestinal inflammation and decreasing histological scores. Moreover, mediators such as COX-2 and iNOS are downregulated and the signaling pathways p38 MAPK, NF-κB, and STAT3 are blocked (Marin).
Research on the Effects of Polyphenols on the Gut Microflora
EGCG, catechin, PACs, and the other phenolic components of TeaHealthy and Enzogenol influence the growth and metabolism of the many different types of bacteria in our gut. Different strains of intestinal bacteria have varying degrees of growth sensitivity to these phenolic compounds and their metabolites. Growth of certain pathogenic bacteria (Clostridium perfringens, C. difficile and Bacteroides species) can be inhibited, while commensal anaerobes like Bifidobacteria and Lactobacilli are not inhibited and can proliferate significantly.
In a study on postmenopausal women supplementation with Isoflavones, genistein, diazein, glycetein from soy, there was an increase in Bifidobacteria within 2 months without using any actual pro-biotics. In this trial, the isoflavones altered dominant bacterial communities with increases in Clostridium coccoides−Eubacterium rectale (Erec) cluster, Faecalibacterium prasnutzii subgroup, and Lactobacillus−Enterococcus group.
This research demonstrates how these compounds change the intestinal environment in a positive way and modulate the intestinal bacterial populations, by acting as metabolic prebiotics. This bioactivity plays an important role in the maintenance of gastrointestinal health (Lee, Tzounis, Etxeberria).
Song P. et al., 2011, Dietary Grape-Seed Procyanidins Decreased Postweaning Diarrhea by Modulating Intestinal Permeability and Suppressing Oxidative Stress in Rats, J. Agric. Food Chem. 59:p6227
Kim YH. et al., 2008. Piceatannol, a stilbene present in grapes, attenuates dextran sulfate sodium-induced colitis. International Immunopharmacology 8:p1698
Mochizuki M1, Hasegawa N. 2004. Therapeutic efficacy of pycnogenol in experimental inflammatory bowel diseases. Phytother Res. 18(12):p1027
Sergent T. et al., 2010, Anti-inflammatory effects of dietary phenolic compounds in an in vitro model of inflamed human intestinal epithelium. Chemico-Biological Interactions 188:p659
Na HK., Surh YJ., 2006, Intracellular signaling network as a prime chemopreventive target of (-)-epigallocatechin gallate. Mol Nutr Food Res. 50(2):p152
Sato K. et al., 1998, Dietary supplementation of catechins and alpha-tocopherol accelerates the healing of trinitrobenzene sulfonic acid-induced ulcerative colitis in rats. J Nutr Sci Vitaminol 44(6):p769
Marín M. 2013. Intestinal anti-inflammatory activity of ellagic acid in the acute and chronic dextrane sulfate sodium models of mice colitis. J Ethnopharmacol. 150(3):p925
Lee HC. et al., 2006, Effect of tea phenolics and their aromatic fecal bacterial metabolites on intestinal microbiota. Res Microbiol. 157(9):p876
Tzounis X. et al., 2011, Prebiotic evaluation of cocoa-derived flavanols in healthy humans by using a randomized, controlled, double-blind, crossover intervention study. Am J Clin Nutr. 93(1):p62
Etxeberria U. et al., 2013. Impact of Polyphenols and Polyphenol-Rich Dietary Sources on Gut Microbiota Composition. J. Agric. Food Chem. 61:p9517
Each capsule contains: 100 mg ENZOGENOL® - Pine bark extract, 200 mg POMx - Pommegranate extract, 75 mg Novasoy - Soybean extract, 200 mg TeaHealthy - Green tea extract. Suitable for Vegetarians, Gluten free, Lactose free, Non-GMO
Keep out of reach of Children. Safety: The active compounds in ENZO Gut Repair are naturally part of our diet from pomegranate, tea, soy products, fruits, vegetables, cocoa, and other plant foods.
If you notice any adverse reactions to ENZO Gut Repair discontinue the capsules, seek the advice of your health practitioner, and please report the adverse event to ENZO Nutraceuticals Ltd.
Adverse reactions/ Precautions: No serious adverse reactions have been reported for the product.
Very occasionally an upset in digestion in form of constipation or diarrhea has occurred. This disappeared very soon after stopping the capsules, and often does not reoccur when the capsules were started again at a lower dose.
The population of people with gut problems, like food intolerances, sensitivities, bloating, inflammation, leaky gut syndrome, dysbiosis, and other issues is constantly increasing. These individuals are a very heterogeneous group and may have different underlying problems with their digestive system. Hence, each individual may show quite different reactions and responses to the use of ENZO Gut Repair. If the product does cause you discomfort or makes your problem worse, discontinue the use and seek advice from your health professional