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Glycyrrhizin Inhibits Replication of SARS Virus in Vitro

Glycyrrhizin Inhibits Replication of SARS Virus in Vitro

Sunday, June 15th 2003

With appropriate patient monitoring, glycyrrhizin may be an effective treatment for severe acute respiratory syndrome (SARS), researchers in Germany report in the June 14th issue of The Lancet. In vitro testing showed that glycyrrhizin, an active component of liquorice roots, is more virotoxic than four other antiviral agents, including ribavirin.

Dr. Jindrich Cinati, of Frankfurt University Medical School, and colleagues incubated two clinical isolates of the SARS coronavirus with Vero cells, which are derived from the kidneys of African green monkeys.

Ribavirin and mycophenolic acid, both inhibitors of inosine monophosphate dehydrogenase, did not reduce viral replication. Pyrazofurin and 6-azauridine, agents that inhibit orotidine monophosphate decarboxylase, inhibited the virus at nontoxic does.

However, glycyrrhizin was far more potent than the other agents, with a selectivity index of 67, compared with an index of 12 for pyrazofurin. Glycyrrhizin affects cellular signaling pathways and transcription factors and increases nitrous oxide production in macrophages.

Glycyrrhizin was less effective when added before virus adsorption than when added after virus adsorption, the report indicates. It was most effective when added to cells both during and after the virus adsorption period.

Glycyrrhizin has been used for the treatment of HIV-1 and hepatitis C infection, with hypertension and hypokalemia infrequently presenting after several months of treatment. However, "treatment of SARS should only be needed for a short time," Dr. Cinati's group points out.

Sourced from NEW YORK (Reuters Health) Jun 12
Lancet 2003;361:2045-2046

Footnote from Ideal Health:

The following products are all helpful in severe respiratory conditions:

Go Breathe Clear
Echinacea with Astragalus and Reishi
Immune Boost
Golden Seal Root
Herbal Throat Formula
Herbal Chest Syrup
Superior Olive Leaf
Vitamin C with Hesperidin Complex

Related health information can be found here:

Common Cold
Echinacea - a potent weapon against infection
Echinacea - natures natural immune tonic
Vitamin C is essential for fighting infections, wound healing and coping with stress
Winter ailments and immune boosting

Related articles can be found here:

Behind the Science of Sambucol Virologist Developed Clinically Tested
Doctors Recommend a Multi-Vitamin a Day
Don't Let the Winter Bug Get You!
Olive Leaf Extract - For Winter Ills and Much More
The Echinacea Experts
The Winter First Aid Kit in a Bottle
Year Round Immune Building

If you need help or advice, you are welcome to email our naturopathic team with your health question.

Disclaimer: The health information presented here has been written for the New Zealand health consumer. It is of a general nature and is only intended to provide a summary of the subjects covered. The information is not intended to be comprehensive or to provide medical advice to you. While all care has been taken to ensure the accuracy of the information, no responsibility or liability is accepted, and no person should act in reliance on any statement contained in the information provided. All health ailments should be treated by a qualified health professional.


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