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Smoking Increases Risk of Familial Pancreatic Cancer

Smoking Increases Risk of Familial Pancreatic Cancer

Thursday, May 29th 2003

A nested case-control study reported in the May issue of Gastroenterology identified smoking and having multiple first-degree relatives with pancreatic cancer as risk factors for developing pancreatic cancer. Based on these findings, the investigators suggest counseling these individuals not to smoke.

"Approximately 10% of pancreatic cancers are inherited, but the factors that affect tumorigenesis in familial pancreatic cancer are unknown," write Stephen J. Rulyak and colleagues from the University of Washington in Seattle. "We sought to determine whether smoking or other factors could predict cancer risk in familial pancreatic cancer kindreds."

This study included 251 members of 28 families, each of which had two or more members with pancreatic cancer. Smoking was an independent risk factor for familial pancreatic cancer (odds ratio [OR], 3.7; 95% confidence interval [CI], 1.8 - 7.6), and smokers developed cancer one decade earlier than did nonsmokers (age of onset, 59.6 vs. 69.1 years; P = .01).

Risk was further increased in men (OR, 5.2), in subjects younger than 50 years (OR, 7.6), and in subjects with affected first-degree relatives (for each additional family member, OR = 1.4; 95% CI, 1.1 - 1.9).

Diabetes was associated with pancreatic dysplasia, but not with pancreatic cancer risk. In one third of families, the mean age of onset decreased by two decades between generations, reflecting genetic anticipation.

"Smoking is a strong, independent risk factor for the development of pancreatic cancer, resulting in a 4-fold increase in risk above and beyond the elevated risk at baseline. Moreover, there may be a dose effect, with risk increasing with five or more years of smoking compared with less than five years of smoking," the authors write. "These factors may be useful in selecting candidates for pancreatic cancer screening. Members of families with multiple pancreatic cancers should be counseled not to smoke."

Solvay Pharmaceuticals, Inc., helped support this study through a grant to one of the authors.

Gastroenterology. 2003;124(5):1292-1299

News Author: Laurie Barclay, MD
CME Author: Bernard M. Sklar, MD, MS

Footnote from Ideal Health:

The following supplements are all useful for kicking the habit:

Quit Smoke
Craving Control Spray
Super Family C
Honeyrose Special Herbal Cigarettes
Herbal Tobacco
Herbal Tobacco Farmers Honeyblend

Related health information can be found here:

Smoking
Immunity
Weight Loss Naturally

Related articles can be found here:

Marijuana Smoking Affects Seminal Fluid, Sperm
Smoking Increases Risk of Familial Pancreatic Cancer

If you need help or advice, you are welcome to email our naturopathic team with your health question.

Disclaimer: The health information presented here has been written for the New Zealand health consumer. It is of a general nature and is only intended to provide a summary of the subjects covered. The information is not intended to be comprehensive or to provide medical advice to you. While all care has been taken to ensure the accuracy of the information, no responsibility or liability is accepted, and no person should act in reliance on any statement contained in the information provided. All health ailments should be treated by a qualified health professional.

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