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Saw Palmetto Extract Effective in Treating Chronic Prostatitis

Saw Palmetto Extract Effective in Treating Chronic Prostatitis

Wednesday, April 30th 2003

Permixon, a compound extracted from the fruit of the American dwarf palm tree Serona repens, also known as saw palmetto, appears to improve symptoms of chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS).

Mesut Remzi, MD, from the Department of Urology at the University of Vienna in Austria, and colleagues presented their findings here at the annual meeting of the American Urological Association.

"Although antimicrobial treatment is usually successful in men with bacterial prostatitis, currently no standardized treatment is available for Category III CP/CPPS," Dr. Remzi and colleagues point out.

The researchers evaluated the efficacy and safety of Permixon in 61 patients with Category IIIB CP/CPPS.

Men were enrolled in two institutions and randomized to six weeks of active treatment with 160 mg Permixon twice daily (n = 32) or a control group, which did not receive a placebo (n = 24). Age, prostate volume, and prostate-specific antigen (PSA) levels were comparable between groups.

The researchers evaluated the response to therapy at six and 12 weeks after treatment based on several efficacy parameters. These included Patients Subjective Global Assessment (SGA); the total NIH Chronic Prostatitis Symptom Index (CPSI); the pain, voiding, and quality of life/impact domains of the CPSI; safety data; PSA level; and prostate volume.

Seventy-five percent of the patients who received Permixon had at least mild improvement in symptoms compared with 20% of the control group. Similarly, 55% of patients who received Permixon reported moderate or marked improvement compared with 16% of the control group. After six weeks, 38% of patients treated with Permixon showed a 30% reduction in total NIH-CPSI compared with 12.5% of the control group, although no difference in this score was observed after 12 weeks.

Despite the improvement in symptoms, prostate volume did not change significantly in either group. In the control group, PSA did not differ from baseline. However, the group taking Permixon experienced median decreases from baseline PSA of 22% after 6 weeks.

According to Dr. Remzi, previous studies have indicated that Permixon has an effect on benign prostatic hyperplasia (BPH) and that it might have an impact on prostatitis.

"Currently, it is the number one treatment for BPH in France and it is also very popular in Germany and Austria for BPH," he told Medscape.

Dr. Remzi suggested that Permixon might treat CP/CPPS by exerting an influence on levels of dihydrotestosterone, or it might exert an anti-inflammatory effect or act as an alpha-blocker.

"Because of these findings, we are now going to do a placebo-controlled trial," he added.

"This study is provocative and interesting," said J. Curtis Nickel, MD, from the Department of Urology at Queen's University in Kingston, Ontario, Canada. "This type of study is what has to be done ? we have to look at everything and compare it to placebo, since herbal therapies may have a role to play in many of these patients." Dr. Nickel estimated that 20% to 30% of his prostatitis patients have tried saw palmetto.

"This is the first study that I know of that has showed a benefit in CP/CPPS for saw palmetto. The study should be repeated with larger numbers and we may be able to show that this type of phytotherapeutic agent may be of benefit," he told Medscape.

The study was self-funded.

AUA 98th Annual Meeting: Abstract 103937. Presented April 26, 2003.

Written by Emma Hitt, PhD

April 28, 2003

Reviewed by Gary D. Vogin, MD

Footnote from Ideal Health:

The following products are all useful for Prostate Health:

Bowel Clear
Cell Food
Enzogenol with ACE and Selenium
Family C - 300 grams
Prosgenia A & B
Men's Formula
Saw Palmetto
Seleno Met
Ultimate Greens Capsules 120's

Related health information can be found here:

Acid and alkaline forming foods
Astra Forte
Cayenne to strengthen the circulation, equalise blood pressure, arrest bleeding & assist with colds
DIM Plus to assist in cancer prevention
Foods to help detoxification
Green Tea as a medicinal beverage
Nutrient use for specific cancers
The Good Health Diet

Related articles can be found here:

Capsaicin Safe, Effective for Intractable Pruritis Ani
High Dairy Product Intake Associated With an Increased Testicular Cancer Risk
Lifestyle Changes May Prevent or Reverse Prostate Cancer
Revised ACS Guidelines for Nutrition, Exercise for Cancer Survivors
Saw Palmetto Extract Effective in Treating Chronic Prostatitis
Second Prostate Cancer Gene Found
Selenium Boosted In Cancer War

If you need help or advice, you are welcome to email our naturopathic team with your health question.

Disclaimer: The health information presented here has been written for the New Zealand health consumer. It is of a general nature and is only intended to provide a summary of the subjects covered. The information is not intended to be comprehensive or to provide medical advice to you. While all care has been taken to ensure the accuracy of the information, no responsibility or liability is accepted, and no person should act in reliance on any statement contained in the information provided. All health ailments should be treated by a qualified health professional.



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