Clinical Study Finds Ginkgo Extract Improves Quality of Life
Monday, April 3rd 2006
A major new study provides good news in the fight against Alzheimer's, as Ginkgo Biloba extract (manufactured by the Dr. Willmar Schwabe Company) has been shown to improve cognitive functions, neuropsychiatric symptoms and the ability to perform daily living activities among typical patients. Results of the double-blind, placebo-controlled trial were presented at the 21st International Conference of Alzheimer's Disease International (ADI).
"This study shows Ginkgo biloba is affective in typical Alzheimer's cases," says Professor A. Napreyenko, principal investigator of the study. "In patients exhibiting the full range of cognitive and non-cognitive features of dementia, Ginkgo Biloba improves cognitive functioning as well as neuropsychiatric symptoms and activities of daily living."
395 outpatients with mild to moderate dementia and neuropsychiatric symptoms (such as depressed mood, anxiety, irritability and indifference) participated in the study. Patients with these symptoms represent the overwhelming majority of Alzheimer's cases in clinical practice. Patients received either 240 mg of Ginkgo Biloba or placebo daily.
After 22 weeks, patients given Ginkgo Biloba showed clear improvement and a highly significant difference to those receiving placebo. Similar statistically significant improvements were found for the Ginkgo Biloba group on all secondary outcome measures. Ginkgo Biloba was also well tolerated.
Positive results of this study confirm earlier findings, including the breakthrough twelve-month U.S. trial by Le Bars et al published in the Journal of the American Medical Association (JAMA, 1997), in which Ginkgo Biloba was shown to stabilize, and in some cases improve, the cognitive performance and social functioning of Alzheimer's patients.
Ginkgo Does Not Affect Bleeding and Coagulation
Researchers point out that controlled clinical trials with Ginkgo Biloba extract do not support the hypothesis that it affects blood coagulation. A review of adverse events observed in 44 clinical trials with a total of 9,772 patients was unable to find a single case of bleeding complications after ingestion of Ginkgo Biloba extract.
A study showed that Ginkgo Biloba, with dosages as high as 480mg per day had no effect on bleeding time, platelet aggregation and coagulation in a group of healthy male volunteers.
Reproduced unabridged from the April - June 2006 issue of Health and Herbal News, with the kind permission of Health and Herbs International Ltd.
Footnote from Ideal Health:
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